Principal Scientist, Immuno-Oncology (remote)

Company: Corbus Pharmaceuticals
Location: Seattle
Posted on: November 22, 2021

Job Description:

The Principal Scientist will be responsible for the development and execution of research plans in support of the selection and advancement of existing and new therapeutic assets for oncology and immune-oncology. The successful applicant will be an exceptional scientist capable of directing research efforts and collaborating with KOLs in specific areas of interest to the company.

Responsibilities include design, coordination, and implementation of key research studies aimed at lead candidate selection, animal proof-of concept, pharmacology, mechanism of action, and other innovative studies aimed at the selection and advancement of lead drug candidates into and through clinical development. This work will be done through contracts with CROs as well as external biotech and academic labs. The successful candidate will publish and present research results at annual research conferences and become a KOL in their own right.

The Principal Scientist will work under the direction of the Sr. Director, Research and work closely with internal medicinal chemistry, clinical and toxicology/DMPK, and regulatory functions to support lead candidate selection and research. The Principal Scientist is responsible for hands-on design, execution and coordination of all research activities on potential lead candidates including lead identification, indication selection, mechanism of action, and in vitro and in vivo pharmacology studies.

The ideal candidate has a proven track record of seven or more years of research experience (ideally in Biotech or Pharma) successfully planning and implementing innovate research studies in oncology aimed at the selection and advancement of clinical candidates into and through development.

You will participate in efforts to identify, evaluate, and develop lead candidates to novel drug targets by interacting with CROs, external biotech and academic labs, and KOLs, to carry out research programs aimed at selecting and advancing lead candidates into and throughout clinical development. You will work closely with an experienced team of interdisciplinary scientists and have regular opportunities to present findings internally, at public conferences and through publications. You will also participate in efforts to identify, evaluate and license new lead candidates from external sources. The ideal candidate will be self-driven, resourceful, innovative, very organized, and enjoy working in a dynamic team environment in a virtual biotech model.

Required Skills/Experiences:

Ph.D. in Cancer Biology, Pharmacology, Immunology or related scientific discipline.
7+ years of experience in pharmaceutical research and development, ideally in industry, in the fields of oncology
Skilled in the development and characterization of monoclonal antibodies. Successful track record of IND filings for immune oncology therapies is desirable
Deep understanding of cellular and molecular mechanisms of oncology, immunology and relevant pathways of angiogenesis, inflammation and fibrosis.
Experience in planning, designing, budgeting, and implementing research studies internally and through external vendors
Working knowledge of 2D and 3D cell culture models of cancer, and mouse xenograft models, including studies in syngeneic models is essential
Knowledgeable in flow cytometry and panel design is an added plus
Familiarity with proteomic and/or genomic and bioinformatic approaches to cell line and drug response profiling, biomarker identification and validation and patient selection strategies is highly desirable
Experience working with external vendors including CRO's.
An outstanding publication/patent record.
Exceptional knowledge of scientific area of responsibility
Ability to ask critical scientific questions and formulate original hypotheses
Demonstrates creativity and novel approaches to solving scientific problems
Excellent written and oral communication skills
A burning desire to make a difference though drug discovery and development

Corbus Culture

Our passion. Our purpose. At Corbus, it starts at our core.
We look for unique talent. Our people are brilliant, they break barriers and are not defined by a title. Eclectic experiences make Corbus a special place to share ideas and grow. At Corbus, transformative ideas can come from anyone, anywhere and anytime. We offer our team flexibility and the opportunity to excel in their professional journey. We provide a welcoming space where collaboration, mentorship and diversity are encouraged. We come together, like no other, to elevate each other and focus on what's best for patients.

About Corbus

Corbus is committed to leveraging our expertise in immunology to fulfill our purpose of developing innovative new medicines that improve the lives of people living with inflammatory, fibrotic, and metabolic diseases, and cancer. Corbus' current pipeline includes small molecules that activate or inhibit the endocannabinoid system and anti-integrin monoclonal antibodies that block activation of TGF--. Corbus is headquartered in Norwood, Massachusetts. For more information on Corbus, visit corbuspharma.com. Connect with us on Twitter, LinkedIn and Facebook.

Corbus Pharmaceuticals Holdings, Inc. is an equal opportunity employer

Keywords: Corbus Pharmaceuticals, Seattle , Principal Scientist, Immuno-Oncology (remote), Healthcare , Seattle, Washington