Principal Scientist, Immuno-Oncology (remote)
Company: Corbus Pharmaceuticals
Posted on: November 22, 2021
The Principal Scientist will be responsible for the development
and execution of research plans in support of the selection and
advancement of existing and new therapeutic assets for oncology and
immune-oncology. The successful applicant will be an exceptional
scientist capable of directing research efforts and collaborating
with KOLs in specific areas of interest to the company.
Responsibilities include design, coordination, and implementation
of key research studies aimed at lead candidate selection, animal
proof-of concept, pharmacology, mechanism of action, and other
innovative studies aimed at the selection and advancement of lead
drug candidates into and through clinical development. This work
will be done through contracts with CROs as well as external
biotech and academic labs. The successful candidate will publish
and present research results at annual research conferences and
become a KOL in their own right.
The Principal Scientist will work under the direction of the Sr.
Director, Research and work closely with internal medicinal
chemistry, clinical and toxicology/DMPK, and regulatory functions
to support lead candidate selection and research. The Principal
Scientist is responsible for hands-on design, execution and
coordination of all research activities on potential lead
candidates including lead identification, indication selection,
mechanism of action, and in vitro and in vivo pharmacology
The ideal candidate has a proven track record of seven or more
years of research experience (ideally in Biotech or Pharma)
successfully planning and implementing innovate research studies in
oncology aimed at the selection and advancement of clinical
candidates into and through development.
You will participate in efforts to identify, evaluate, and develop
lead candidates to novel drug targets by interacting with CROs,
external biotech and academic labs, and KOLs, to carry out research
programs aimed at selecting and advancing lead candidates into and
throughout clinical development. You will work closely with an
experienced team of interdisciplinary scientists and have regular
opportunities to present findings internally, at public conferences
and through publications. You will also participate in efforts to
identify, evaluate and license new lead candidates from external
sources. The ideal candidate will be self-driven, resourceful,
innovative, very organized, and enjoy working in a dynamic team
environment in a virtual biotech model.
Ph.D. in Cancer Biology, Pharmacology, Immunology or related
7+ years of experience in pharmaceutical research and development,
ideally in industry, in the fields of oncology
Skilled in the development and characterization of monoclonal
antibodies. Successful track record of IND filings for immune
oncology therapies is desirable
Deep understanding of cellular and molecular mechanisms of
oncology, immunology and relevant pathways of angiogenesis,
inflammation and fibrosis.
Experience in planning, designing, budgeting, and implementing
research studies internally and through external vendors
Working knowledge of 2D and 3D cell culture models of cancer, and
mouse xenograft models, including studies in syngeneic models is
Knowledgeable in flow cytometry and panel design is an added
Familiarity with proteomic and/or genomic and bioinformatic
approaches to cell line and drug response profiling, biomarker
identification and validation and patient selection strategies is
Experience working with external vendors including CRO's.
An outstanding publication/patent record.
Exceptional knowledge of scientific area of responsibility
Ability to ask critical scientific questions and formulate original
Demonstrates creativity and novel approaches to solving scientific
Excellent written and oral communication skills
A burning desire to make a difference though drug discovery and
Our passion. Our purpose. At Corbus, it starts at our core.
We look for unique talent. Our people are brilliant, they break
barriers and are not defined by a title. Eclectic experiences make
Corbus a special place to share ideas and grow. At Corbus,
transformative ideas can come from anyone, anywhere and anytime. We
offer our team flexibility and the opportunity to excel in their
professional journey. We provide a welcoming space where
collaboration, mentorship and diversity are encouraged. We come
together, like no other, to elevate each other and focus on what's
best for patients.
Corbus is committed to leveraging our expertise in immunology to
fulfill our purpose of developing innovative new medicines that
improve the lives of people living with inflammatory, fibrotic, and
metabolic diseases, and cancer. Corbus' current pipeline includes
small molecules that activate or inhibit the endocannabinoid system
and anti-integrin monoclonal antibodies that block activation of
TGF--. Corbus is headquartered in Norwood, Massachusetts. For more
information on Corbus, visit corbuspharma.com. Connect with us on
Twitter, LinkedIn and Facebook.
Corbus Pharmaceuticals Holdings, Inc. is an equal opportunity
Keywords: Corbus Pharmaceuticals, Seattle , Principal Scientist, Immuno-Oncology (remote), Healthcare , Seattle, Washington
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