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Principal Associate Scientist, Target ID and Validation, Tumor Immunology

Company: 2seventy Bio
Location: Seattle
Posted on: March 19, 2023

Job Description:

How you'll make an impact:
Our Seattle site is currently seeking a Principal Associate Scientist within the Tumor Immunology group to support pre-clinical efforts in the early product development space of CAR and TCR T cell therapies. This lab-based role will enable the candidate to contribute to our oncology discovery research team working closely with fellow scientists to drive innovative cell therapy programs forward. The ideal candidate is passionate about addressing the critical unmet medical needs of cancer patients; displays a high level of curiosity and creative problem-solving; and is keen to work within cross-functional teams.
About the team:
2seventy bio is passionate about developing best-in-class T cell therapies that deliver new hope for patients with cancer. Whether we are transforming the field of immuno-oncology, or finding new ways to iterate and improve, we are driven by a personal commitment to changing the lives of our patients. The tumor immunology group is focused on fully realizing the potential of unlocking the complexities of tumors and the hostile microenvironment that they create.
How you'll spend your time:
As a Principal Research Associate, you'll help to bring more patients more time by:

  • Cloning CAR/TCR constructs into lentiviral vectors
  • Designing and executing in vitro assays to characterize and evaluate the functionality of lead CAR/TCR T cell therapeutic candidates
  • Culturing and characterizing tumor cell lines, including engineering of gene overexpressing and knockout cell lines
  • Performing in vitro immunological assays, including but not limited to, flow cytometry, ELISA/MSD, cytotoxicity analysis
  • Collaborating with cross-functional and cross-site teams to plan experiments and obtain test materials and reagents
  • Contributing to study design, execution, and data analysis
  • Compiling and presenting data to functional teams
  • Maintaining detailed and accurate documentation in an electronic lab notebook

    Who you are and what you've accomplished:

    • BS/MS in cell biology, immunology, oncology, or related discipline with 5+ years experience
    • Extensive experience in molecular biology techniques, including cloning, cell line engineering, lentivirus production, WES/western blot and qPCR
    • Experience with mammalian cell culture, such as tumor cell lines - primary T cell experience is a plus
    • Experience with multi-parameter flow cytometry and FACS
    • Experience with standard immunological assays to assess T cell functionality, such as MSD, Luminex, ELISA, and Incu-Cyte is a plus
    • Working knowledge of various software (e.g. Microsoft Office, FlowJo, GraphPad Prism, FACSDiva, Geneious)
    • Ability to effectively plan and organize work activities to meet schedules and deadlines
    • Strong organizational skills to ensure timely and robust documentation of experiments and presentation of dataq
    • Effectively work independently and as part of a collaborative team comprised of multiple functional groups

Keywords: 2seventy Bio, Seattle , Principal Associate Scientist, Target ID and Validation, Tumor Immunology, Healthcare , Seattle, Washington

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