Associate Scientist, Gene Delivery Process and Analytical Development- Cell Therapy

Company: Bristol-Myers Squibb
Location: Seattle
Posted on: May 26, 2023

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: .Cell Therapy is one of the most groundbreaking new forms of cancer treatments being studied today. With therapies only in their infancy and BMS's continued investment in our Cell Therapy capabilities, the growthpotential of this science, your career, and the ability to help patients are incredible.Position Summary:The Associate Scientist will join the Gene Delivery Process and Analytical Development (GDPAD) organization supporting process development, production, and characterization of viral vectors, which are critical to generating BMS's groundbreaking cell therapies. The candidate will help drive next-generation viral vector platform development and support the advancement of clinical programs.Responsibilities:

• Design, execute, and troubleshoot upstream development experiments supporting next-generation AAV and LVV production
• Identify, onboard, and develop novel upstream technologies in collaboration with internal and external partners
• Optimize perfusion production processes and support clinical and commercial scale-up
  • Provide experimental design and executional support to team members
    • Support cross-functional development efforts e.g. downstream process development, high-throughput process development
    • Support research-to-development transition endeavors, including early-stage/pipeline molecular assessment activities
    • Support vector attribute identification initiatives
      • Generate representative crude harvest material to support downstream development activities
      • Actively participate and support lab maintenance, buildout, and continuous improvement initiatives
      • Work independently and within teams to design, execute, and analyze experiments
      • Maintain accurate and detailed laboratory notebook and documentation
      • Summarize and present data in group meetings and contribute to group discussions and team strategy
        • Represent GDPAD within cross-functional teams
        • Support tech transfer and on-going activities with external collaborators and service providers (CDMOs, CROs)
        • Author technical reports and study memosBasic Qualifications:
          • STEM degree with 2+ years of relevant industry experience; title/compensation will ultimately be commensurate with education, experience, and skillset
          • Experience with suspension culture of mammalian cells in shake flasks and small stirred tank bioreactors
          • Hands on experience in process development
          • Working knowledge of scale up parameters for stirred tank bioreactors
          • Proven ability to design experiments with DoE approaches, execute DoE designs and interpret the results
          • Independently motivated with ability to work in teams
          • Ability to communicate clearly and concisely through oral presentation and technical writing
          • Ability to leverage literature, internal and external resources to solve problems
          • Desire to identify and advance the cutting edge
          • Possess a growth mindset and the ability to thrive in a fast-paced, highly collaborative environmentPreferred Qualifications:
            • Degree in biological or chemical engineering, biochemistry, or bio-related field
            • Experience in the development of viral vectors (e.g. adeno-, retro-, lenti-), including successful transfer for GMP manufacturing
            • Experience interfacing with contract manufacturing and development organizations
            • Experience giving external presentations and contributing to peer-reviewed publications
            • Experience with transfection-based processes
            • Experience with upstream processes intensification e.g. fed batch and perfusion development, process-analytical technology (PAT)
            • Experience with cell line development
            • Experience with media/feed development
            • Experience with process modeling, mechanistic modeling, and statistical interpretation of results
            • Knowledge of metabolic flux and metabolic control analysis
            • Experience with data pipelines and knowledge management
            • Experience with single-use technologies
            • Experience with late-stage developmentAdditional Job Requirements: Position Handles Hazardous MaterialsThe starting compensation for this jobis a range from $75,000-$95,000 plus incentive cash and stock opportunities (based on eligibility).The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed.Final, individual compensation will be decidedbased on demonstratedexperience.Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our websiteBenefitofferingsaresubject to the terms and conditions of the applicable plans then in effectand may include the following: Medical, pharmacy, dental and vision care. Wellbeing supportsuch asthe BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support.Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility.Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.If you have a passion for taking on new challenges in a fast-paced and dynamic environment, are dedicated to excellence and want to make a difference, we're excited to hear from you! The ideal candidate has a proven track record of innovation, demonstrated skill set and knowledge of viral vectors, in gene editing, analytical development, and is excited to take on new challenges in a fast-paced and dynamic environment.BMSCART#LI-OnsiteIf you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as "Transforming patients' lives through science--- ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site ProtocolPhysical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement.BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Bristol-Myers Squibb, Seattle , Associate Scientist, Gene Delivery Process and Analytical Development- Cell Therapy, Healthcare , Seattle, Washington