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Principal Scientist, Nanoparticle Technology Platform Lead, Non-Viral Delivery - Cell Therapy

Company: Bristol-Myers Squibb
Location: Seattle
Posted on: May 15, 2022

Job Description:

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. -In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference. Cell Therapy is one of the most groundbreaking new forms of cancer treatments being studied today. With therapies only in their infancy and BMS's continued investment in our Cell Therapy capabilities, the growth potential of this science, your career, and the ability to help patients are incredible. We are seeking an enthusiastic, self-driven individual to join the Gene Delivery Process & Analytical Development team and lead the development of next-generation technologies to enable non-viral delivery for our cell therapy processes. This Principal Scientist will be responsible for developing novel nanoparticle technologies from early strategy and project conception through technology development. Responsibilities: -

  • Develop nanoparticle formulations (i.e., LNPs) to enable delivery of multiple payloads (RNA, DNA, protein) into primary T cells for cell therapy applications
  • Develop methods to implement nanoparticle technologies into cell therapy processes
  • Transfer nanoparticle technology to internal and/or external GMP manufacturing
  • Author technical reports, patents, and peer-reviewed publications, and contribute to regulatory documents Basic Qualifications:
    • Degree in Chemistry, Chemical Engineering, Bioengineering, Biochemistry, or related discipline
    • 8+ years (B.S., M.S.) or 4+ years (Ph.D.) of experience developing nanoparticle technologies
    • Familiarity with lipid synthesis and design of novel lipid compounds
    • Familiarity with lipid nanoparticle formulation generation with microfluidic mixing instrumentation, as well as LNP characterization methods (DLS, Ribogreen, HPLC-ELSD, etc.)
    • Familiarity with mammalian cell culture, preferably with primary cells
    • Previous work interfacing with contract manufacturing and development organizations
    • Familiarity with developing GMP manufacturing processes for globally-regulated products, such as vaccines, biologics, or cell & gene therapies
    • Effective communication skills with proven ability to work effectively as a member of a multidisciplinary team
    • Previous experience managing and mentoring scientists
    • Strong organization, time management, and problem-solving skills with attention to detail
    • Experience and working knowledge of concepts including but not limited to immunology, gene editing, cell therapy, etc. If you want to challenge yourself, accelerate your career, and give new hope to patients, there's no better place than here with our Cell Therapy team. Full of incredible and dedicated team members, those working on CAR-T and other forms of Cell Therapy are transforming patients' lives through science. From studying individualized cell lines to making brand new discoveries, this bold and personal discipline allows you to grow your career while making a lasting impact on the field of medicine. Join us today. BMSCART Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. - Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture. To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S. Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement. Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Bristol-Myers Squibb, Seattle , Principal Scientist, Nanoparticle Technology Platform Lead, Non-Viral Delivery - Cell Therapy, IT / Software / Systems , Seattle, Washington

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