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Associate Scientist, Gene Editing and Delivery Technology

Company: Celgene
Location: Seattle
Posted on: December 6, 2019

Job Description:

Req #: 1901733
Location: Seattle, Washington, United States
Job Category: Technical Development
Work Location: 400 Dexter Ave N. 98109
Organization: Bioengineering
Employee Status: Full-time
Job Type: Regular
Juno Therapeutics, a Celgene company, is developing clinical-stage, novel cellular immunotherapies based on two distinct and complementary platforms Chimeric Antigen Receptors (CARs) and T Cell Receptors (TCRs) technologies. Our goal is to revolutionize medicine by re-engaging the body s immune system to treat cancer.

The Editing and Delivery Technology group is seeking an enthusiastic, self-driven Associate Scientist who will be the key contributor with focus on transforming novel editing and delivery technologies from benchtop protocols to at-scale operations compatible with T-cell manufacturing platforms for therapeutic drug products. To be able to conduct validation and optimization to support process development, the individual will have to develop deep understanding of Juno s existing proprietary T-cell manufacturing platforms and keen insight of how to improve them by introducing new technologies. The desired candidate is also expected to have excellent analytical abilities and DOE experience.

Primary Responsibilities

  • Support the development of robust, scalable processes integrated by gene editing and delivery technologies for manufacturing T-cell drug products.
  • Support evaluation and validation of new technologies for at-scale operations and drug manufacturing platforms.
  • Execute and coordinate experiments and assays in a timely manner and with sense of urgency.
  • Analyze the assay readouts and experimental data for troubleshooting and to discover potential levers for improvement.
  • Maintain communications with stakeholders to ensure the developed technologies meeting product and platform requirements.
  • Prepare samples/materials and track their sources to support experiments (cells, nucleic acids, protein-nucleic acid complexes and necessary reagents)
  • Maintain accurate and detailed laboratory notebook and documentation
  • Author technical reports and operating procedures
    Basic Qualifications
    • B.S. in Molecular and Cellular Biology, Bioengineering, Virology, Biochemistry, or any biological sciences disciplines
    • 5 years of pharmaceutical industry experience in technology development and validation
    • 4 years of industry experience in primary cell culture, 2 years in primary human T-cells
    • 2 years of industry experience in electroporation or any transfection/transduction (viral or non-viral) techniques
      • Experience with BD Flow Cytometer instrumentation (FACSCanto, Fortessa, Symphony, Aria, etc.) and analysis software (FlowJo, FACSDiva, FCSExpress, etc.)
      • DOE methodology and statistical software (JMP, R, Spotfire, Prism, etc.)
        • Independently motivated to accomplish given tasks and work in teams
        • Ability to communicate clearly and concisely through oral presentations and technical writing
          Preferred Qualifications
          • Working knowledge in molecular biology techniques, such as construct design, DNA/RNA amplification and analysis, and gene cloning, Western blot, ELISA etc.
          • Knowledge and experience of cellular assays (e.g. cytokine, cytotoxicity or proliferation assays) is a plus
            • Experience with Lentivirus and Adeno-associated virus is a plus
            • Experience with CRISPR/Cas9 KO/I
              • Ability to work collaboratively in a cross-functional scientific environment
              • Knowledge and concepts of state-of-the-art development of cell therapies
                About Us

                COMMITTED TO IMPROVING THE LIVES OF PATIENTS WORLDWIDE

                At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our vision as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions.

                "At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients."

                There are more than 300 clinical trials at major medical centers using compounds from Celgene. Investigational compounds are being studied for patients with incurable hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes, chronic lymphocytic leukemia (CLL), non-Hodgkin s lymphoma (NHL), triple-negative breast cancer and pancreatic cancer. As committed as we are to clinical accomplishment, we are equally committed to patient support, which is a guiding principle at Celgene. We believe all who can benefit from our discoveries should have the opportunity to do so. Celgene puts patients first with industry-leading programs that provide information, support and access to our innovative therapies. Associated topics: antibody, dietary, dietetic, food, histotechnologist, immunoassay, medicine, microbiology, physiologist, virus

Keywords: Celgene, Seattle , Associate Scientist, Gene Editing and Delivery Technology, Other , Seattle, Washington

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