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Scientist, Upstream Process Development - Cell Therapy

Company: Bristol Myers Squibb
Location: Seattle
Posted on: January 12, 2021

Job Description:

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.Cell Therapy is one of the most groundbreaking new forms of cancer treatments being studied today. With therapies only in their infancy and BMS's continued investment in our Cell Therapy capabilities, the growth potential of this science, your career, and the ability to help patients are incredible.We are seeking an individual to join the Viral Vector & Gene Editing Process Development team. Our team develops process and technology underpinning critical raw materials used in the manufacturing of engineered T cells, including viral vector. The primary focus of this Scientist is to drive process development of scalable, manufacturing-friendly upstream viral vector processes. The Scientist is expected to take ownership of key parts of the project as well as contribute to high-level strategies and technology platforms. This position will be responsible for communicating to internal and external collaborators, making sure all relevant stakeholders are informed about the data and status of development timelines.Responsibilities:* Work in a collaborative, cross-functional team responsible for developing robust, scalable vector production and purification processes* Plan and execute experimental work to develop and optimize upstream unit operations for viral vector production* Act as subject matter expert for stirred tank reactor equipment and operation, guide best-practice implementation and training* Provide technical and scientific mentorship to junior staff* Work with MSAT and manufacturing colleagues to ensure successful transfer and scale-up of upstream processes* Represent viral vector and process development to leadership, stakeholders, and within cross-functional teams* Support tech transfer and on-going activities with external collaborators and service providers (CMOs, CROs)* Assist in the creation of next generation technologies and platforms for viral vector and gene editing* Author technical reports, patents, and peer-reviewed publicationsBasic Qualifications:* B.A./B.S./M.S. with 8+ years of biotechnology experience; Ph.D. in Chemical Engineering, Biochemistry, Virology, Bioengineering, Biology or related field, or equivalent experience.* Experience developing and optimizing scalable, manufacturing-friendly processes for the production of biologics* Deep understanding of mammalian cell culture; expertise in bioreactor and control software operation* Previous work interfacing with internal/external manufacturing and development organizations* Demonstrated excellence in experimental design, using DoE principles followed by independent execution and data analysis* Strong problem-solving and risk-based decision-making skills* Proven ability to work in a fast-paced, multi-product, matrixed environment* Effective communication including presentations to convey scientific concepts to research scientists, management teams, and external academic and industrial organizations* Understanding of GMP/ICH guidelines and regulationsPreferred Qualifications:* Documented experience developing GMP manufacturing processes for globally-regulated products, such as vaccines, biologics, or cell & gene therapies* Experience in the development of clinical viral vector manufacturing processes, including successful scale-up and transfer into GMP manufacturing* Prior success in managing small, high performing teams* Experience authoring regulatory documents, including IND and BLA filings* Proven track record of high-quality external presentations and peer-reviewed publications* Experience with viral titering methods, including ELISA, qPCR and cell-based assaysIf you want to challenge yourself, accelerate your career, and give new hope to patients, there's no better place than here with our Cell Therapy team. Full of incredible and dedicated team members, those working on CAR-T and other forms of Cell Therapy are transforming patients' lives through science. From studying individualized cell lines to making brand new discoveries, this bold and personal discipline allows you to grow your career while making a lasting impact on the field of medicine. Join us today.BMSCARTAround the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Keywords: Bristol Myers Squibb, Seattle , Scientist, Upstream Process Development - Cell Therapy, Other , Seattle, Washington

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