Scientist, Upstream Process Development - Cell Therapy
Company: Bristol Myers Squibb
Location: Seattle
Posted on: January 12, 2021
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Job Description:
At Bristol Myers Squibb, we are inspired by a single vision -
transforming patients' lives through science. In oncology,
hematology, immunology and cardiovascular disease - and one of the
most diverse and promising pipelines in the industry - each of our
passionate colleagues contribute to innovations that drive
meaningful change. We bring a human touch to every treatment we
pioneer. Join us and make a difference.Cell Therapy is one of the
most groundbreaking new forms of cancer treatments being studied
today. With therapies only in their infancy and BMS's continued
investment in our Cell Therapy capabilities, the growth potential
of this science, your career, and the ability to help patients are
incredible.We are seeking an individual to join the Viral Vector &
Gene Editing Process Development team. Our team develops process
and technology underpinning critical raw materials used in the
manufacturing of engineered T cells, including viral vector. The
primary focus of this Scientist is to drive process development of
scalable, manufacturing-friendly upstream viral vector processes.
The Scientist is expected to take ownership of key parts of the
project as well as contribute to high-level strategies and
technology platforms. This position will be responsible for
communicating to internal and external collaborators, making sure
all relevant stakeholders are informed about the data and status of
development timelines.Responsibilities:* Work in a collaborative,
cross-functional team responsible for developing robust, scalable
vector production and purification processes* Plan and execute
experimental work to develop and optimize upstream unit operations
for viral vector production* Act as subject matter expert for
stirred tank reactor equipment and operation, guide best-practice
implementation and training* Provide technical and scientific
mentorship to junior staff* Work with MSAT and manufacturing
colleagues to ensure successful transfer and scale-up of upstream
processes* Represent viral vector and process development to
leadership, stakeholders, and within cross-functional teams*
Support tech transfer and on-going activities with external
collaborators and service providers (CMOs, CROs)* Assist in the
creation of next generation technologies and platforms for viral
vector and gene editing* Author technical reports, patents, and
peer-reviewed publicationsBasic Qualifications:* B.A./B.S./M.S.
with 8+ years of biotechnology experience; Ph.D. in Chemical
Engineering, Biochemistry, Virology, Bioengineering, Biology or
related field, or equivalent experience.* Experience developing and
optimizing scalable, manufacturing-friendly processes for the
production of biologics* Deep understanding of mammalian cell
culture; expertise in bioreactor and control software operation*
Previous work interfacing with internal/external manufacturing and
development organizations* Demonstrated excellence in experimental
design, using DoE principles followed by independent execution and
data analysis* Strong problem-solving and risk-based
decision-making skills* Proven ability to work in a fast-paced,
multi-product, matrixed environment* Effective communication
including presentations to convey scientific concepts to research
scientists, management teams, and external academic and industrial
organizations* Understanding of GMP/ICH guidelines and
regulationsPreferred Qualifications:* Documented experience
developing GMP manufacturing processes for globally-regulated
products, such as vaccines, biologics, or cell & gene therapies*
Experience in the development of clinical viral vector
manufacturing processes, including successful scale-up and transfer
into GMP manufacturing* Prior success in managing small, high
performing teams* Experience authoring regulatory documents,
including IND and BLA filings* Proven track record of high-quality
external presentations and peer-reviewed publications* Experience
with viral titering methods, including ELISA, qPCR and cell-based
assaysIf you want to challenge yourself, accelerate your career,
and give new hope to patients, there's no better place than here
with our Cell Therapy team. Full of incredible and dedicated team
members, those working on CAR-T and other forms of Cell Therapy are
transforming patients' lives through science. From studying
individualized cell lines to making brand new discoveries, this
bold and personal discipline allows you to grow your career while
making a lasting impact on the field of medicine. Join us
today.BMSCARTAround the world, we are passionate about making an
impact on the lives of patients with serious diseases. Empowered to
apply our individual talents and diverse perspectives in an
inclusive culture, our shared values of passion, innovation,
urgency, accountability, inclusion and integrity bring out the
highest potential of each of our colleagues.Bristol Myers Squibb
recognizes the importance of balance and flexibility in our work
environment. We offer a wide variety of competitive benefits,
services and programs that provide our employees with the resources
to pursue their goals, both at work and in their personal
lives.
Keywords: Bristol Myers Squibb, Seattle , Scientist, Upstream Process Development - Cell Therapy, Other , Seattle, Washington
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