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Scientist, Molecular Assay Developement

Company: Bristol Myers Squibb
Location: Seattle
Posted on: January 13, 2021

Job Description:

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.Cell Therapy is one of the most groundbreaking new forms of cancer treatments being studied today. With therapies only in their infancy and BMS's continued investment in our Cell Therapy capabilities, the growth potential of this science, your career, and the ability to help patients are incredible.Product & Analytical Development (P&AD) advances knowledge for cell therapy products, gene delivery tools, and ancillary materials to enable current and future generation cell therapy development. The P&AD organization delivers product and analytical development strategies, analytical technology and assay automation, product characterization data packages, and QC release and characterization methods for cell therapy, gene delivery platforms, and residuals.Withing the P&AD team, the Gene Editing Molecular Analytics group is seeking a Senior Associate Scientist or Scientist to pioneer on the development of analytical methods in support of engineered T-cell programs. The ideal candidate has a proven track record of innovation, analytical development, demonstrated skill set and knowledge in molecular biology, gene editing, and is excited to take on new challenges in a fast-paced and dynamic environment. This incumbent is responsible for analytical method development to enable process development, characterization and QC release of multiple gene edited T cell products.Primary Responsibilities* Develop analytical methods for characterization of on-target and off-target genomic modifications in engineered T cells.* Develop, optimize, and qualify analytical methods to enable process development, in-process testing, characterization, stability testing, and product release.* Effective communications with stakeholders to ensure the developed methods meeting product and regulatory requirements.* Support the development of complete suite analytical method documentation such as protocols, development and qualification reports, standard operating procedures, QC test methods, and analytical sampling plans* Method transfer to external and internal testing labs.* Maintain accurate and detailed laboratory notebook and documentation.* Author technical and regulatory documents.Basic Qualifications* Ph.D. (Scientist) in a biological science discipline or MS/BS (Senior Associate Scientist) with 5+ years of relevant molecular assay development experience.* Skillful with molecular biology techniques (primer/probe design, qPCR, ddPCR, RT-PCR) and cell manipulation (transfection and transduction).* Experience with next generation sequencing (NGS)-based methods.* Detail-orientated, organized, working knowledge of electronic notebook use.* Strong time management skills with the capacity to meet deadlines and prioritize work from multiple projects.* Excellent oral and written technical communication skills.* Strong sense of responsibility, accountability, and integrity.Preferred Qualifications* 1+ years of industry experience in assay development or related fields.* Extensive working experience with droplet digital PCR (ddPCR).* Experience with CRISPR/Cas9 gene editing.If you want to challenge yourself, accelerate your career, and give new hope to patients, there's no better place than here with our Cell Therapy team. Full of incredible and dedicated team members, those working on CAR-T and other forms of Cell Therapy are transforming patients' lives through science. From studying individualized cell lines to making brand new discoveries, this bold and personal discipline allows you to grow your career while making a lasting impact on the field of medicine. Join us today.BMSCARTAround the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Keywords: Bristol Myers Squibb, Seattle , Scientist, Molecular Assay Developement, Other , Seattle, Washington

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