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Senior Scientist, Engineered T Cell Biology

Company: Bristol Myers Squibb
Location: Seattle
Posted on: January 14, 2021

Job Description:

At Bristol Myers Squibb, we are inspired by a single vision --- transforming patients--- lives through science. In oncology, hematology, immunology and cardiovascular disease --- and one of the most diverse and promising pipelines in the industry --- each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.The BMS Immuno-Oncology and Cell Therapy Thematic Research Center is dedicated to research supporting development of novel cellular therapies based on two distinct and complementary platforms --- Chimeric Antigen Receptor (CAR) and Engineered T Cell Receptor (eTCR) technologies. Our goal is to revolutionize medicine by re-engaging the body---s immune system to treat cancer.The Engineered T Cell Biology Team is seeking an experienced and driven immunologist, molecular/cellular biologist or bioengineer with an advanced analytics or computational biology background to help build and advance our cell therapy and immuno-oncology portfolio. This position will be responsible for working with the team to curate, leverage and build high-content datasets (eg; scRNAseq/CITEseq, scATACseq, scTCRseq, high-parameter FACS or spectral cytometry, etc) that permit the interrogation of cellular heterogeneity across an array of functional and dysfunctional states. The successful candidate will have working knowledge of immunology and expertise in the analysis of multi-omic platforms. This position is in a highly collaborative, innovate and rapidly evolving environment and interfaces with multiple teams and functions across the company. Our team---s overall goal is to modulate T cell health, function and potency to iterate on improving the overall therapeutic potential of cellular therapies for BMS--- Research and Early Development Pipeline.Responsibilities for this role will include, but are not limited to, the following:Application of multivariate and/or machine learning approaches to curated datasets in support of the interrogation of T cells, CAR T or eTCR T cells in functional and dysfunctional statesPropose, devise and coordinate wet lab experiments and data analysis to inform next-gen strategiesWork with our NGS team to develop and/or bring novel profiling technologies in-houseWork with our Informatics and Predictive Sciences colleagues on adapting pipelines and extending analytics capabilities within our teamProvide cell biology and high-content data analysis subject matter expertise and guidance to cross-functional teams evaluating a diverse array of cell therapy engineering challengesLeverage existing internal capabilities and datasets as well as be willing and eager to apply novel ideas from the literature and other disciplines to innovate in a rapidly evolving fieldHelp develop and mentor junior scientists on our teamBuild constructive relationships across the organization and with our key business partners to achieve common goals Qualifications:Senior Scientist: PhD in immunology, molecular/cellular biology, bioengineering or similar discipline with at least 3 years of successful postdoctoral experience as demonstrated by a strong publication record plus 3 years of industry experience, or a BS/MS with 13 years of relevant industry experienceScientist II: PhD with 2-3 years of successful postdoctoral or a combination of postdoctoral and industry experience, or a BS/MS with 10 years of relevant industry experience.Broad working knowledge of platforms and technologies to evaluate cellular heterogeneity including but not limited to high-dimensional FACS, spectral cytometry, CyTOF, transcriptional or epigenetic assessment, metabolomics, population tracking/time-series, and/or other single-cell approaches.Broad working knowledge of multivariate statistics or machine learning analytical workflows (eg; JMP, python, R, MATLAB)Computational cytometry and/or spatial analysis experience a plusSelf-motivated as an individual contributor but also excited about working in a highly collaborative matrixed environmentExcellent written and verbal communication, and strong organizational skills to facilitate managing multiple projects at onceBristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.BMSCARTAround the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Full time

Keywords: Bristol Myers Squibb, Seattle , Senior Scientist, Engineered T Cell Biology, Other , Seattle, Washington

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