Senior Scientist, Engineered T Cell Biology
Company: Bristol Myers Squibb
Location: Seattle
Posted on: January 14, 2021
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Job Description:
At Bristol Myers Squibb, we are inspired by a single vision ---
transforming patients--- lives through science. In oncology,
hematology, immunology and cardiovascular disease --- and one of
the most diverse and promising pipelines in the industry --- each
of our passionate colleagues contribute to innovations that drive
meaningful change. We bring a human touch to every treatment we
pioneer. Join us and make a difference.The BMS Immuno-Oncology and
Cell Therapy Thematic Research Center is dedicated to research
supporting development of novel cellular therapies based on two
distinct and complementary platforms --- Chimeric Antigen Receptor
(CAR) and Engineered T Cell Receptor (eTCR) technologies. Our goal
is to revolutionize medicine by re-engaging the body---s immune
system to treat cancer.The Engineered T Cell Biology Team is
seeking an experienced and driven immunologist, molecular/cellular
biologist or bioengineer with an advanced analytics or
computational biology background to help build and advance our cell
therapy and immuno-oncology portfolio. This position will be
responsible for working with the team to curate, leverage and build
high-content datasets (eg; scRNAseq/CITEseq, scATACseq, scTCRseq,
high-parameter FACS or spectral cytometry, etc) that permit the
interrogation of cellular heterogeneity across an array of
functional and dysfunctional states. The successful candidate will
have working knowledge of immunology and expertise in the analysis
of multi-omic platforms. This position is in a highly
collaborative, innovate and rapidly evolving environment and
interfaces with multiple teams and functions across the company.
Our team---s overall goal is to modulate T cell health, function
and potency to iterate on improving the overall therapeutic
potential of cellular therapies for BMS--- Research and Early
Development Pipeline.Responsibilities for this role will include,
but are not limited to, the following:Application of multivariate
and/or machine learning approaches to curated datasets in support
of the interrogation of T cells, CAR T or eTCR T cells in
functional and dysfunctional statesPropose, devise and coordinate
wet lab experiments and data analysis to inform next-gen
strategiesWork with our NGS team to develop and/or bring novel
profiling technologies in-houseWork with our Informatics and
Predictive Sciences colleagues on adapting pipelines and extending
analytics capabilities within our teamProvide cell biology and
high-content data analysis subject matter expertise and guidance to
cross-functional teams evaluating a diverse array of cell therapy
engineering challengesLeverage existing internal capabilities and
datasets as well as be willing and eager to apply novel ideas from
the literature and other disciplines to innovate in a rapidly
evolving fieldHelp develop and mentor junior scientists on our
teamBuild constructive relationships across the organization and
with our key business partners to achieve common goals
Qualifications:Senior Scientist: PhD in immunology,
molecular/cellular biology, bioengineering or similar discipline
with at least 3 years of successful postdoctoral experience as
demonstrated by a strong publication record plus 3 years of
industry experience, or a BS/MS with 13 years of relevant industry
experienceScientist II: PhD with 2-3 years of successful
postdoctoral or a combination of postdoctoral and industry
experience, or a BS/MS with 10 years of relevant industry
experience.Broad working knowledge of platforms and technologies to
evaluate cellular heterogeneity including but not limited to
high-dimensional FACS, spectral cytometry, CyTOF, transcriptional
or epigenetic assessment, metabolomics, population
tracking/time-series, and/or other single-cell approaches.Broad
working knowledge of multivariate statistics or machine learning
analytical workflows (eg; JMP, python, R, MATLAB)Computational
cytometry and/or spatial analysis experience a plusSelf-motivated
as an individual contributor but also excited about working in a
highly collaborative matrixed environmentExcellent written and
verbal communication, and strong organizational skills to
facilitate managing multiple projects at onceBristol-Myers Squibb
recognizes the importance of balance and flexibility in our work
environment. We offer a wide variety of competitive benefits,
services and programs that provide our employees the resources to
pursue their goals, both at work and in their personal
lives.BMSCARTAround the world, we are passionate about making an
impact on the lives of patients with serious diseases. Empowered to
apply our individual talents and diverse perspectives in an
inclusive culture, our shared values of passion, innovation,
urgency, accountability, inclusion and integrity bring out the
highest potential of each of our colleagues.Bristol Myers Squibb
recognizes the importance of balance and flexibility in our work
environment. We offer a wide variety of competitive benefits,
services and programs that provide our employees with the resources
to pursue their goals, both at work and in their personal lives.
Full time
Keywords: Bristol Myers Squibb, Seattle , Senior Scientist, Engineered T Cell Biology, Other , Seattle, Washington
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