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Scientist, Gene Editing Assay Development

Company: Bristol Myers Squibb
Location: Seattle
Posted on: January 15, 2021

Job Description:

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.Scientist, Gene Editing Assay DevelopmentBristol-Myers Squibb company, is developing clinical-stage, novel cellular immunotherapies based on two distinct and complementary platforms - Chimeric Antigen Receptors (CARs) and T Cell Receptors (TCRs) technologies. Our goal is to revolutionize medicine by re-engaging the body's immune system to treat cancer.The Gene Editing Molecular Analytics group is seeking an enthusiastic, self-driven Scientist to pioneer on the development of analytical methods in support of engineered T-cell programs. The ideal candidate has a proven track record of innovation, analytical development, demonstrated skill set and knowledge in molecular biology, gene editing, and is excited to take on new challenges in a fast-paced and dynamic environment. This incumbent is responsible for analytical method development to enable process development, characterization and QC release of multiple gene edited T cell products.Primary Responsibilities* Develop phase appropriate program-specific analytical strategies for gene editing* Develop analytical methods for characterization of engineered T cells including quantification of on-target and off-target modifications.* Develop, optimize, and qualify analytical methods to enable process development, in-process testing, characterization, stability, and product release.* Effective communications with stakeholders to ensure the developed methods meeting product and regulatory requirements.* Support the development of complete suite analytical method documentation such as protocols, development and qualification reports, standard operating procedures, QC test methods, and analytical sampling plans* Method transfer to external and internal testing labs.* Maintain accurate and detailed laboratory notebook and documentation.* Author technical and regulatory documents.Basic Qualifications* Ph.D. in a biological science discipline with 3+ years of relevant gene editing experience.* Extensive knowledge and experience with CRISPR/Cas9 gene editing.* Knowledge and experience with next generation sequencing and molecular assay design and development.* Skillful with molecular biology techniques (primer/probe design, qPCR, ddPCR, RT-PCR) and cell manipulation (transfection and transduction).* Detail-orientated, organized, working knowledge of electronic notebook use.* Strong time management skills with the capacity to meet deadlines and prioritize work from multiple projects.* Excellent oral and written technical communication skills.* Strong sense of responsibility, accountability, and integrity.Preferred Qualifications* 2+ years of industry experience in assay development or related fields.* Experience with droplet digital PCR.About UsBristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immuno-science and fibrosis.Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Keywords: Bristol Myers Squibb, Seattle , Scientist, Gene Editing Assay Development, Other , Seattle, Washington

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