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Senior Research Associate or Associate Scientist, Process Transfer and Implementation

Company: Bristol Myers Squibb
Location: Seattle
Posted on: May 6, 2021

Job Description:

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.Cell Therapy is one of the most groundbreaking new forms of cancer treatments being studied today. With therapies only in their infancy and BMS's continued investment in our Cell Therapy capabilities, the growth potential of this science, your career, and the ability to help patients are incredible.Job DescriptionThe Department Cell Therapy Process Sciences and Technology is seeking an enthusiastic, self-motivated individual to join its innovative, multi-disciplinary team focusing on process transfer and implementation for gene editing and delivery technologies. As a member of the Gene Delivery and Editing Technology team, the individual will support the advancement of the T-cell engineering technologies for manufacturing immunotherapeutic products. This role will provide a challenging but rewarding opportunity for career development. A successful candidate is expected to be well-versed in T-cell manufacturing process for immunotherapeutic drug product manufacturing and the instruments utilized in the processes.Education and ExperiencesAssociate Scientist* B.S. in Bioengineering, Chemical Engineering, Molecular and Cellular Biology, Biochemistry, or related disciplines with 6+ years of relevant industrial experiences.* M.S. in Bioengineering, Chemical Engineering, Molecular and Cellular Biology, Biochemistry, or related disciplines. 4+ years of relevant industrial experiences is preferred.Senior Research Associate* B.S. in Bioengineering, Chemical Engineering, Molecular and Cellular Biology, Biochemistry, or related disciplines with 2+ years of relevant industrial experiences.* M.S. in Bioengineering, Chemical Engineering, Molecular and Cellular Biology, Biochemistry, or related disciplines with 0-2 years of relevant industrial experiences is preferred.Expertise and Skills* Experience and working knowledge with electroporation procedures and instrumentation (eg Lonza Nucleofector, Thermo Neon, MaxCyte) for CRISPR knock-out or transgene delivery applications.* Experience and working knowledge with automated T-cell culture and expansion systems (eg GE Xuri, Lonza Cocoon)* Experience and working knowledge with T-cell engineering process and instruments (eg leukapheresis, separation, activation, viral transduction, etc.)* Experience with flow cytometry analyzers and data interpretation* DOE methodology and relevant statistical software (JMP, R, etc.)* Experience with CMO/CRO communication and management* Experience with tech transfer and project management through full product/technology development life cycle* Knowledge with GMP compliance of hardware, reagents and consumables for biologics.* Knowledge with viral vector (eg LVV, AAV) transduction is a plus.* knowledge with CRISPR/Cas9-based or other gene editing techniques is a plus.* Experience with microfluidic technologies or instruments is a plus* Programing skills tailored for instrument control and automation is a plus* Independently motivated to accomplish given tasks and work in teams* Ability to communicate clearly and concisely through oral presentations and technical writing* Ability to work collaboratively in a multi-disciplinary cross-functional environment.Duties and Responsibilities* Support the development of robust, scalable processes of gene editing and delivery technologies for manufacturing T-cell drug products.* Experimentally validate new technologies to support technical due diligence.* Transfer technologies from CRO/CMO and to the downstream internal users/recipients in manufacturing setting.* Maintain communications with internal stakeholders and external vendors to ensure the technology transferring and implementation meeting manufacturing requirements and IND timelines.* Being an active liaison in supervising suppliers during the development of GMP compliant materials and consumables.* Maintain accurate and detailed laboratory notebook and documentation* Author technical reports and operating proceduresIf you want to challenge yourself, accelerate your career, and give new hope to patients, there's no better place than here with our Cell Therapy team. Full of incredible and dedicated team members, those working on CAR-T and other forms of Cell Therapy are transforming patients' lives through science. From studying individualized cell lines to making brand new discoveries, this bold and personal discipline allows you to grow your career while making a lasting impact on the field of medicine. Join us today.BMSCARTAround the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or any part of the recruitment process direct your inquiries to (see below) Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Keywords: Bristol Myers Squibb, Seattle , Senior Research Associate or Associate Scientist, Process Transfer and Implementation, Other , Seattle, Washington

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