Research Scientist 3 (Req# 197136)
Company: MSACL Connect
Posted on: June 24, 2022
Overcoming the challenges of implementing high value tests in
the clinical lab Company: University of Washington Medical Center,
Department of Lab Medicine and Pathology Location: Seattle
Position: Research Scientist 3 (Req# 197136) Description:The
Hoofnagle Lab has an outstanding opportunity for a Research
Scientist/Engineer 3. The person in this role will perform routine
laboratory procedures and support research and development of
analytical chemistry techniques to quantify proteins and small
molecules in complex mixtures, including urine, serum, plasma, cell
culture, blood spots, cerebral spinal fluid, and frozen and
preserved tissues. One of the overarching goals of the Hoofnagle
Lab is development of reference method procedures for proteins in
complex mixtures to serve as the gold standard for patient care and
clinical research. This person will design and develop novel
quantitative assays and perform routine testing that can be used to
support clinical research studies. It is expected that these
fundamental studies will lay the foundation for high-quality
clinical assays in the future.
--- Develop, validate, and implement new LC-MS assays to quantify
proteins and small molecules from typical clinical chemistry sample
types to expand understanding of the pathophysiology of different
--- Characterize antibody and affinity reagents using a variety of
biochemical techniques (e.g. SDS-PAGE, SE-HPLC, N-glycan profiling,
peptide mapping, etc.).
--- Independently perform a variety of laboratory techniques (e.g.
affinity purification, tryptic digestion, solid-phase-extraction,
HPLC-MS, ELISA, etc.).
--- Perform established assays using targeted proteomics and
metabolomics technologies for the sensitive and specific
quantification of proteins and small molecules.
--- Manage projects of moderate size and scope; initiate new
projects, identify long- and short-term project goals, and design &
prioritize experiments to determine feasibility of set
--- Communicate with outside scientists in academia and industry to
develop collaborative projects.
--- Contribute, analyze, and present research data using summary
graphs for publication and grant submission; present and update
research progress at lab meeting or joined group settings.
--- Optimize protocols and troubleshoot experiments as necessary to
generate relevant data. Continuously evaluate existing methods with
an eye toward improving data quality, reducing costs, and/or
--- Monitor assignments and projects to ensure they are completed
within specified time frame; accommodate schedule changes to
cooperatively accomplished required daily work.
--- Perform work accurately and precisely; recognize, correct, and
document errors when they occur.
--- Maintain complete, accurate, legible records. Author, review,
and revise SOPs and manuscripts for publication.
--- Provide ongoing feedback and updates to supervisor/project
coordinator and actively solicit input on overcoming roadblocks and
impediments to success.
--- Train new employees and guest technicians in experimental
procedures and assays, instrument maintenance, laboratory safety,
and general lab procedures.
--- Perform routine instrument maintenance as well as
troubleshooting; serve as point-of-contact with service
--- Coordinate sample receiving/shipments with collaborators;
assist with sample tracking, inventory maintenance, data entry, and
--- Prepare and verify reagents; monitor and order supplies.
--- Perform other duties as assigned.
Master's degree in Life Sciences (including chemistry, biophysics,
biochemistry, etc.) and 5+ years of working experience. Previous
experience with mass spectrometry is required. Must be able to
communicate effectively in English, both verbally and in
PhD degree in Life Sciences (including chemistry, biophysics,
biochemistry, etc.) and 3+ years of relevant experience. The ideal
candidate with have demonstrated the ability to think and work
independently. They will have strong organizational skills and a
keen attention to detail, be able to clearly express oneself both
verbally and in writing, and have the capacity to carefully analyze
the data they generate. It is also highly desirable that the
applicant be comfortable working in a team environment, be able to
manage their own workload effectively, be careful and fastidious,
and have strong computer skills with a working knowledge of general
MS Office applications.
Specific experience with the following techniques is highly
--- Proteomics, metabolomics, peptide mapping, and/or quantitative
LC-MS assay development.
--- Quality control, standard operating procedures, and method
--- Excellent writing skills as evidenced by peer-reviewed
publications and participation in constructing funding
To apply, please visit this link:
Keywords: MSACL Connect, Seattle , Research Scientist 3 (Req# 197136), Other , Seattle, Washington
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