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Senior Research Associate

Company: Alpha Consulting Corp.
Location: Seattle
Posted on: May 28, 2023

Job Description:

SENIOR RESEARCH ASSOCIATE SEATTLE, WA 100% Onsite. Pay range is 67.59 to 70.00. Project Description: The Cell Therapy Product Sciences department is seeking two Senior Research Associate to support the development of gene engineered T cell products. Product Sciences is responsible for developing and executing mechanisms of action and characterization studies to support the development of gene-engineered T cell therapies. The primary focus of the Senior Research Associate - Product Sciences role will be to build CAR/TCR T cell product and process understanding in support of early and late-stage CAR T with a particular focus on exploratory/investigational needs for late-stage programs. Primarily, support late-stage drug product and manufacturing process understanding by performing exploratory studies and investigational analyses including experimental design and execution, statistical/correlative analyses of existing data sets, writing technical reports, presenting data, etc. Design and deploy in-depth characterization of gene engineered T cells using flow cytometry, genome-wide expression analysis, metabolic profiling, and/or additional cutting-edge analytical techniques. Participate in cross-functional teams to support the development of gene engineered T cell therapeutic platforms. Identification and development of novel analytical approaches for interrogating gene engineered T cell function. Develop and maintain relationships with external collaborators and service providers. Serve as T cell biology subject matter expert in multidisciplinary team setting, that includes non-clinical, clinical, regulatory, and CMC functions. Perform and manage instrument and method troubleshooting . Author, review, and approve technical documents, including methods, protocols, reports, and SOPs . Learn and apply ICH/FDA/EMEA guidance and current thinking. Required Skills: Successful candidates will have a very strong foundation in cell-based assays (flow cytometry, proliferation, cytotoxicity, cytokine release, etc.) and some background in human T cell biology and/or other immune cell types. Experience with implementation and optimization of a broad range of in vitro cell-based and molecular assays is critical (especially multi-color flow cytometry and cell culture). This role is highly collaborative and requires attention to detail, a healthy sense of urgency, a strong desire to learn, and a passion for exploratory and investigational science. Furthermore, a demonstrated ability to support cross-functional teams and independently design and execute studies to meet project goals is very highly desirable (albeit not a requirement and will depend on the applicant's individual qualifications). This 12+ month position starts ASAP. Please E-MAIL your resume (attachment to email) with rate and availability to Krysty: krysty@alphaconsulting.com ALPHA'S REQUIREMENT #23-00964 MUST BE ELIGIBLE TO WORK IN THE U.S. AS AN HOURLY W2 EMPLOYEE PDN-993554a7-7bcf-40d3-a2dd-12062b80b68c

Keywords: Alpha Consulting Corp., Seattle , Senior Research Associate, Other , Seattle, Washington

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